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Welcome to the homepage for the Bioinformatics Research Laboratory.
 
BRL News:

« Genome Portrait of MCF-7 in NYT, Genome Res. »  
A map of breakpoints in the MCF-7 breast cancer cell line made by BRL grad student Oliver A. Hampton is featured in The New York Times ("The Chaos Inside a Cancer Cell") and is published in Genome Research (Hampton et al., 2008).


« Pash »  A new version of Pash, 2.0, has been released! It improves mapping accuracy in the presence of indels, increases speed by up to a factor of 3 over the previous version, and provides the option of refining Pash anchorings by performing banded alignment. Contributed by Pash's main developer, Cristian Coarfa. Please see the license and download page to acquire the new version.

« Genomic Triangulation »  Our paper Human-Specific Changes of Genome Structure Detected by Genomic Triangulation as well our contributions to the Evolutionary and Biomedical Insights from the Rhesus Macaque Genome paper have been published. Data used in the ancestral reconstructions, including genome pairwise comparisons, BAC mappings, fosmid mappings, and markers, as well as the reconstructions themselves and detected breakpoints are available through Genboree.

« Pash »  A new version of Pash has been released! Improvements in usage, dependencies, accuracy, scratch space, and small-query mapping; also, the introduction of new scoring methods. Contributed by Pash's main developer, Cristian Coarfa. Please see the license and download page to acquire the new version.

« H.s. Chr3 & Chr12 »  The Human Chr 3 & 12 Nature articles have been published. Figure 2 in both papers were contributed by Alan Harris. See the Genboree news items for more information and links.

« Gap Map »  We applied the Gap Map concept to the Rhesus-Human Comparative Linkage Map.

« Rhesus »  Our integrated comparative map of rhesus, chimp, and human includes matepair chains, contigs, and our latest mappings of 16,495 Rhesus BACs to the Human genome using the PGI method.

Note: The rhesus PGI paper has been published in Genome Research!

« Sequencing »  We have developed the Tagamizer program to parse and identify short sequence tags present in a sequencing read. The Tagamizer program is now available for download.

 

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( Modified Feb 09, 2010 )